School personnel information


IKAWA Masahito

Date of Birth



Biology of Reproduction, Animal Experimentation, Developmental Biology

Mail Address

Mail Address




Organization 【 display / non-display

  • 2001.04.01 - 2004.03.31, Genome Information Research Center, Research Assistant

  • 2004.04.01 - 2007.03.31, Research Institute for Microbial Diseases, Associate Professor

  • 2007.04.01 - 2012.10.31, Research Institute for Microbial Diseases, Associate Professor

  • 2012.11.01 - , Research Institute for Microbial Diseases, Professor

  • 2012.11.01 - , Graduate School of Pharmaceutical Sciences

  • 2013.03.01 - , Graduate School of Medicine

  • 2012.12.01 - , Immunology Frontire Research Center

Education 【 display / non-display

Osaka University Faculty of Pharmaceutical Science  Graduated 1992.03
Osaka University Graduate School, Division of Pharmaceutical Sciences  Completed 1997.03

Research topics 【 display / non-display

  • Laboratory animal science, Developmental biology

  • Developmental biology, Obstetrics and gynecology, Urology, Animal production science

Academic Society Membership 【 display / non-display

  • Japanese Association for Laboratory Animal Science

  • Society for the Study or Reproduction


Academic Papers 【 display / non-display

  • Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive, Miyata H, Satouh Y, Mashiko D, Muto M, Nozawa K, Shiba K, Fujihara Y, Isotani A, Inaba K, Ikawa M., Science.,50(6259) 442-445, 2015.10, Papers

  • Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility., Tokuhiro K, Ikawa M, Benham AM, Okabe M., Proc Natl Acad Sci U S A.,109(10):3850-5., 2012.03, Papers

  • Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer., Okada Y, Ueshin Y, Isotani A, Saito-Fujita T, Nakashima H, Kimura K, Mizoguchi A, Oh-Hora M, Mori Y, Ogata M, Oshima RG, Okabe M, Ikawa M., Nat Biotechnol.,25 (2) p233-237, 2007.02, Papers

  • The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs., Inoue N, Ikawa M, Isotani A, and Okabe M., Nature,434:234-8, 2005.03, Papers

  • The putative chaperone calmegin is required for sperm fertility., Ikawa M, Wada I, Kominami K, Watanabe D, Toshimori K, Nishimune Y, Okabe M., Nature.,387(6633):607-11, 1997.06, Papers

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Awards 【 display / non-display

  • JSPS PRIZE, Masahito Ikawa, Japan Society for the Promotion of Science, 2013.02

  • SRD Outstanding Presentation Award (oral presentation), 2016.09

  • DGD Wiley Blackwell Prize 2015, Daisuke Mashiko, Samantha A Young, Masanaga Muto, Hirotaka Kato , Kaori Nozawa, Masaki Ogawa, Taichi Noda, Yeon-Joo Kim , Yuhkoh Satouh, Yoshitaka Fujihara, Masahito Ikawa, Japanese Society of Developmental Biologists, 2015.06

Media report 【 display / non-display

  • OSAKA, Japan, Oct. 2 (UPI) -- Researchers in Japan may have found a method for reliable, reversible male contraception by blocking a protein in mice using two, UPI, 2015.10

  • Male Birth Control Treatment Could Focus on Sperm Proteins, Not Hormones, Richard Dawkins Foundation, 2015.10

  • Researchers identify new molecular target for male contraceptives, Pharma Business International, 2015.10

  • Newly Identified Sperm-Specific Protein Bolsters Prospects Of Male Contraceptive, IFLScience, 2015.10

  • Potential Male Birth Control Pill Is Found in an Immunosuppressant Drug, Newsweek, 2015.10

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Lecture / Exhibition 【 display / non-display

  • Lecture Series from Osaka University, Japan, CRISPR/Cas9 mediated genome editing in mice, 2016.01

Outside Activity Management 【 display / non-display

  • Academic society, Society for the Study of Reproduction, Program committee Member, 2012.07 - 2014.07