School personnel information


TAKAGI Junichi


Protein Chemistry, Structural Biology


Organization 【 display / non-display

  • 2003.04.01 - , Institute for Protein Research, Professor

Education 【 display / non-display

Tokyo Institute of Technology Graduate School, Division of Science and Engineering  Completed Ph.D. 1990.03

Employment Record 【 display / non-display

Tokyo Institute of Technology, Faculty of Science, Instructor 1990.04 - 1990.06
Tokyo Institute of Technology, Faculty of Bioscience and Biotechnology, Instructor 1990.07 - 2000.03
Harvard Medical School, Dept of Pathology, Instructor 2000.04 - 2002.07
Harvard Medical School, Dept of Pediatrics, Assistant Professor 2002.08 - 2003.03
Osaka University, Institute for Protein Research, Professor 2003.04 - 2012.03
Osaka University, Institute for Protein Research, Professor 2012.04 -

Research topics 【 display / non-display

  • Structural biochemistry-related

  • Structural biochemistry-related

  • Structural biochemistry-related

  • Protein engineering based on the structural information
    Structural biochemistry-related

Academic Society Membership 【 display / non-display

  • The Japanese Society on Thrombosis and Hemostasis

  • Japanese Biochemical Society

  • The Protein Society


Academic Papers 【 display / non-display

  • Structural basis for semaphorin signalling through the plexin receptor., Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J., Nature,467(7319):1123-7., 2010.10, Papers

  • The constitutive high affinity Met binding site in the kringle domain is dispensable for the signaling activity of hepatocyte growth factor., Umitsu M, Sakai K, Tamura-Kawakami K, Matsumoto K, Takagi J, Journal of biochemistry, 2020.01, Papers

  • Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer., Miao W, Sakai K, Sato H, Imamura R, Jangphattananont N, Takagi J, Nishita M, Minami Y, Matsumoto K, Cancer science, 2019.07, Papers

  • Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor., Sakai K, Passioura T, Sato H, Ito K, Furuhashi H, Umitsu M, Takagi J, Kato Y, Mukai H, Warashina S, Zouda M, Watanabe Y, Yano S, Shibata M, Suga H, Matsumoto K, Nature chemical biology,15(6) 598-606, 2019.06, Papers

  • Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach., Jangphattananont N, Sato H, Imamura R, Sakai K, Terakado Y, Murakami K, Barker N, Oshima H, Oshima M, Takagi J, Kato Y, Yano S, Matsumoto K, International journal of molecular sciences,20(12), 2019.06, Papers

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Books 【 display / non-display

  • Special, Crystal structure of reelin repeats. in Reelin Glycoprotein, biology, structure and roles in health and disease, Takagi, J., Springer, 2008.07