School personnel information

写真b

TAGAMI Shinji


Keyword

Alzheimer disease

Mail Address

Mail Address

URL

http://www.med.osaka-u.ac.jp/pub/psy/www/jp/index.html

Gender

Male

Organization 【 display / non-display

  • 2003.07.01 - 2007.03.31, Graduate School of Medicine, Research Assistant

  • 2007.04.01 - 2019.07.31, Graduate School of Medicine, Assistant Professor

  • 2019.08.01 - , Graduate School of Medicine, Associate Professor

Education 【 display / non-display

Osaka University Faculty of Medicine  Graduated 1996.03
Osaka University Graduate School, Division of Medical Sciences  Completed 2001.03

Research topics 【 display / non-display

  • The cleavage precision of presenilin gamma secretase

 

Academic Papers 【 display / non-display

  • Semagacestat Is a Pseudo-Inhibitor of γ-Secretase., Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M., Cell Reports,21(1):259-273., 2017.10, Papers

  • γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43., Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M., Cell Reports,3(1):42-51, 2013.01, Papers

  • The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system, Yanagida K, Okochi M (C.A.), Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tkuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M, EMBO Molecular Medicine,1:p223-235, 2009.06, http://www3.interscience.wiley.com/cgi-bin/fulltext/122454317/HTMLSTART, Papers

  • Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1., Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Nakayama T,Chiba S, Takeda M, et al., Molecular and Celluar Biology,2008 Jan;28(1):165-76. Epub 2007 Oct 29, 2008.01, http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17967888&dopt=AbstractPlus, Papers

  • A novel protein, RTN-xS, interacts with both Bcl-xL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity., Tagami S, Eguchi Y, Kinoshita M, Takeda M and Tsujimoto Y., Oncogene 19: 5736-5746, 2000,19: 5736-5746,, 2000.11, http://www.nature.com/onc/journal/v19/n50/abs/1203948a.html, Papers

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Books 【 display / non-display

  • Other, 100 Papers Selection ANNUAL REPORT OF OSAKA UNIVERSITY-Academic Achievement-/2007-2008, Tagami, S.; Okochi, M.; Yanagida, K.; Ikuta, A.; Fukumori, A.; Matsumoto, N.; Ishizuka-Katsura, Y.; Nakayama, T.; Itoh, N.; Jiang, J.; Nishitomi, K.; Kamino, K.; Morihara, T.; Hashimoto, R.; Tanaka, T.; Kubo, T.; Chiba, S.; Takeda, M., Osaka University, 2009.05

  • Special, Amyloid-beta 42 generating process may have a biological role in regulation of Notch signaling intensity, Tagami S, Okochi M, Fukumori A, Takeda M, Jpn. J. Neuropsychopharmachology, ISBN, 1340-2544, 2008.11