Details of a Researcher

写真b

KURAOKA Isao

Keyword	DNA damage, DNA repair, Mutagenesis, Carcinogenesis
Gender	Male

2001.04.01 - 2002.03.31, Institute for Molecular and Cellular Biology, Research Assistant, full time
2002.04.01 - 2006.03.31, Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Research Assistant, full time
2008.04.01 - , Department of Materials Engineering Science, Graduate School of Engineering Science, Associate Professor, full time

Osaka University Completed

PhD

1996.03

Risk sciences of radiation/ Chemicals, Molecular biology, Living organism molecular science
The aim of research is to elucidate DNA damage response network in mammals and molecular genesis of genetic diseases that have a defect in DNA repair network. Particularly, I am interested in the analysis of molecular mechanisms of transcription-coupled DNA repair. I am investigating whether and/or how pol II stall DNA lesions for TCR and/or bypass them for transcriptional mutagenesis.

Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in, Chijiwa S, Masutani C, Hanaoka F, Iwai S, Kuraoka I., Carcinogenesis, 31:388-93., 2010.03, Papers
RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS., Kuraoka I, Suzuki K, Ito S, Hayashida M, Kwei JS, Ikegami T, Handa H, Nakabeppu Y, Tanaka K., DNA Repair, 2007.06, Papers
XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients., Ito, S., Kuraoka, I., Chymkowitch, P., Compe, E., Takedachi, A., Ishigami, C., Coin, F., Egly, J. M., and Tanaka, K., Mol Cell, 2007.04, Papers(In Japanese)
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage., Groisman, R., Polanowska, J., Kuraoka, I., Sawada, J., Saijo, M., Drapkin, R., Kisselev, A. F., Tanaka, K., and Nakatani, Y., Cell, 2003.05, Papers
Removal of oxygen free-radical-induced 5',8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells., Kuraoka, I., Bender, C., Romieu, A., Cadet, J., Wood, R. D., and Lindahl,T, Proc Natl Acad Sci U S A, 2000.04, Papers

Textbook, DNA damage recognition and nucleotide excision repair in mammalian cells., Wood, R. D., Araujo, S. J., Ariza, R. R., Batty, D. P., Biggerstaff, M., Evans, E., Gaillard, P. H., Gunz, D., Koberle, B., Kuraoka, I., Moggs, J. G., Sandall, J. K., and Shivji, M. K., Cold Spring Harb Symp Quant Biol, 2000.05