School personnel information


NISHINO Kunihiko


Microbiology, Drug resistance, Virulence, Chemotherapy, Efflux Pump


Organization 【 display / non-display

  • 2005.11.01 - 2007.03.31, The Institute of Scientific and Industrial Research, Assistant Professor

  • 2007.04.01 - 2007.05.31, The Institute of Scientific and Industrial Research, Assistant Professor

  • 2007.06.01 - 2009.01.31, The Institute of Scientific and Industrial Research, Assistant Professor

  • 2009.02.01 - 2015.02.15, The Institute of Scientific and Industrial Research, Associate Professor

  • 2015.02.16 - , The Institute of Scientific and Industrial Research, Professor

Education 【 display / non-display

Osaka University Graduate School, Division of Pharmaceutical Sciences  Completed Ph.D. 2003.03

Employment Record 【 display / non-display

Fellow, Japan Society for the Promotion of Science for Young Scientist 2001.04 -
Postdoctoral Fellow, Japan Society for the Promotion of Science for Young Scientists 2003.04 -
Research Associate, Osaka University 2005.11 -
Investigator, PRESTO, Japan Science and Technology Agency 2006.10 -
Assistant Professor (Specially Appointment), Osaka University 2007.04 -
Assistant Professor, Osaka University 2007.06 -
Associate Professor, Osaka University 2009.01 -
Professor, Osaka University 2015.02 -

Research topics 【 display / non-display

  • Regulatory network of multidrug resistance in pathogenic bacteria and complex functional systems
    Bacteriology-related, Genome biology-related, Pharmaceutical hygiene and biochemistry-related

  • Roles of xenobiotic transporters in cellular physiology
    Pharmaceutical hygiene and biochemistry-related, Chemistry and chemical methodology of biomolecules-related, Bacteriology-related

  • Single cell measurement of bacterial drug efflux in femtoliter chamber array
    Pharmaceutical hygiene and biochemistry-related, Bacteriology-related, Molecular biology-related

  • Signal transduction systems of bacterial virulence and drug resistance
    Bacteriology-related, Life, health and medical informatics-related, Pharmaceutical hygiene and biochemistry-related

Academic Society Membership 【 display / non-display

  • Japanese Biochemical Society

  • Japanese Association for Infectious Diseases

  • Japanese Society of Chemotherapy

  • Pharmaceutical Society of Japan

  • Japanese Society for Bacteriology

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Academic Papers 【 display / non-display

  • Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket, Nakashima R, Sakurai K, Yamasaki S, Nishino K, Yamaguchi A, Nature,doi:10.1038/nature10641, 2011.12,, Papers

  • Bacterial Multidrug Exporters: Insights into Acquisition of Multidrug Resistance, Nishino K, Science,Vol. 307. no. 5711, p. 864, 2005.02, Papers

  • The multidrug efflux pump MdtEF protects against nitrosative damage during the anaerobic respiration in Escherichia coli, Zhang Y, Xiao M, Horiyama T, Zhang Y, Li X, Nishino K, Yan A, J. Biol. Chem.,286:26576-84, 2011.07,, Papers

  • Dissecting the PhoP Regulatory Network of Escherichia coli and Salmonella enterica, Zwir I, Shin D, Kato A, Nishino K, Latifi T, Solomon F, Hare JM, Huang H, Groisman EA, Proc. Natl. Acad. Sci. USA.,102, 2862-2867, 2005.02, Papers

  • Virulence and Drug Resistance Roles of Multidrug Efflux Systems of Salmonella enterica, Nishino K, Latifi T, Groisman EA, Mol. Microbiol.,59, 126-141, 2006.01, Papers

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Patents / Utility models / Designs 【 display / non-display

  • Japan, Modulators for the Receptor of Autoinducer-2, Nobuo Kato, Masamitsu Hiraoka, Junko Ohkanda, Tomikazu Kawano, Akihito Yamaguchi, Takahiro Hirata, Kunihiko Nishino, Shigeyuki Ebisu and B. L. Bassler, 特願2007-056450(Registration), 2007.03

  • United States, L-cysteine producing microorganism and method for producing L-cysteine, Takagi H, Nakamori S, Yamaguchi A, Nishino K, 20050221453(Registration), 2004.10

Awards 【 display / non-display

  • Inoue Research Award for Young Scientists, Kunihiko Nishino, Inoue Foundation for Science, 2006.02

  • Kuroya Award, Kunihiko Nishino, Japanese Society for Bacteriology, 2003.04

  • The Young Scientists Prize by the Minister of Education, Culture, Sports and Technology, Japan, Kunihiko Nishino, Ministry of Education, Culture, Sports, Science and Technology, Japan, 2008.04

  • Nature-Invitrogen Biotechnology Award, Kunihiko Nishino, Nature, Invitrogen, 2006.05

  • Young Scientist Award, Kunihiko Nishino, Science, American Association for the Advancement of Science (AAAS), GE Healthcare, 2005.02

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