School personnel information

写真b

UEDA Keiji


Keyword

virus, receptor, gene regulation, replication, virus-host interaction, latent infection, lytic infection, virus engineering

URL

http://www.med.osaka-u.ac.jp:80/pub/virus/

Organization 【 display / non-display

  • 2001.04.01 - 2005.03.31, Graduate School of Medicine, Associate Professor

  • 2005.04.01 - 2006.06.30, Division of Preventive and Environmental Medicine, Graduate School of Medicine, Associate Professor

  • 2009.07.01 - 2011.03.31, Division of Preventive and Environmental Medicine, Graduate School of Medicine, Professor

  • 2011.04.01 - , Division of Medicine, Graduate School of Medicine, Professor

Education 【 display / non-display

Osaka University Faculty of Medicine  Graduated 1984.03
Osaka University Graduate School, Division of Medical Sciences Internal Medicine Completed Ph.D 1990.03

Employment Record 【 display / non-display

Assistant Professor, Osaka University School of Medicine 1999.01 - 2002.03
Associate Professor, Osaka University Graduate School of Medicine 2002.04 - 2006.06
Professor, Hamamatsu University School of Medicine 2006.07 - 2009.06
Professor, Osaka University Graduate School of Medicine 2009.07 -

Research topics 【 display / non-display

  • Viruses are biological organisms? They are just complexes of (glyco-) protein, lipid and genome element (nucleic acids). Once such complexes enter the cells convenient for them, the world shall be changed to the viral universe, where the gene expression, the replication, reconstitution of the viral structure progress automatically like factories and finally, millions of daughter viruses are produced. The viral strategies from the attachment/entry to egress of daughter viruses is very tactic and elaborate. We have been trying to disclose such elaborate tactics of hepatitis B virus and Kaposi's sarcoma-associated herpesvirus and going for viral control/regulation to treat virus-caused diseases.
    Virology-related

  • 1) Analysis of the relationship between virus-host factors in viral infection
    2) Identification of unknown viral receptor, its application for establishment of Infection system, and analysis of viral pathogenesis
    3) Exploration of universal vaccine production technique based on the viral engineering
    Virology-related, Cell biology-related, Molecular biology-related

Academic Society Membership 【 display / non-display

  • The Japan Society of Gastroenterology

  • American Society for Microbiology (ASM)

  • Japan's Cancer Association

  • The Japan Society of Hepatology

 

Academic Papers 【 display / non-display

  • Inhibition of LINE-1 Retrotransposition by Capsaicin., Nishikawa Y, Nakayama R, Obika S, Ohsaki E, Ueda K, Honda T., International Journal of Molecular Sciences,19(10) E3243, 2018.10, Papers

  • Importance of Promyelocytic Leukemia (PML) for Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication., Md. Golzar Hossain, Eriko Ohsaki, Tomoyuki Honda and Keiji Ueda., Frontiers in Microbiology,9/ 2324, 2018.10, Papers

  • vFLIP upregulates IKKε, leading to spindle morphology formation through RelA activation., Yang Z, Honda T, Ueda K., Virology,522 106-121, 2018.07, Papers

  • St6gal1 knockdown alters HBV life cycle in HepAD38 cells, 81. Surya Agung Priyambadaa, Ryo Misakia, Toru Okamoto, Takao Ohashia, Keiji Ueda, Yoshiharu Matsuura, Kazuhito Fujiyama, iochemical and Biophysical Research Communications,503(3):1841-1847, 2018.07, Papers

  • Full-length isoforms of KSHV LANA accumulate in the cytoplasm of cells undergoing the lytic cycle of replication., 77. H. Jacques Garriguesa, Kellie Howarda, Serge Barcya, Minako Ikomaa, Ashlee V. Mosesb, Gail H. Deutschc, David Wud, Keiji Ueda and Timothy M. Rose,91(24) e01532-17, 2017.12, Papers

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Books 【 display / non-display

  • Special, human herpesvirus 8, Ueda, K., Hokkaido University Publishers, ISBN, 978-4-8329-8229-1 C3047, 2017.10

  • Special, Mechanism of the latency and reactivation of KSHV, Ohsaki E., Yada K., Ueda K., Nippon Rinsho., ISSN, 00471852, 2006.03