School personnel information

写真b

OKADA Yoshiaki


Keyword

Endothelial cell, Robo4, Gene regulation, Epigenetics, vascular permeability

URL

http://www.phs.osaka-u.ac.jp/homepage/b018/

Organization 【 display / non-display

  • 2006.07.01 - 2007.03.31, Center for Advanced Eduction and Research in Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Research Assistant

  • 2007.04.01 - 2011.03.31, Center for Advanced Eduction and Research in Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Assistant Professor

  • 2011.04.01 - 2012.03.31, Environmental Pharamaceutical Sciences, Graduate School of Pharmaceutical Sciences, Assistant Professor

  • 2012.04.01 - 2012.05.15, Graduate School of Pharmaceutical Sciences, Assistant Professor

  • 2012.05.16 - , Medical Pharmacy, Graduate School of Pharmaceutical Sciences, Associate Professor

Education 【 display / non-display

Osaka University Faculty of Pharmaceutical Science  Graduated 1998.03
Osaka University Graduate School, Division of Pharmaceutical Sciences  Completed 2000.03
Osaka University Graduate School, Division of Pharmaceutical Sciences  Completed Ph.D. 2003.03

Employment Record 【 display / non-display

Beth Israel Deaconess Medical Center/Harvard Medical School 2003.09 - 2006.06

Research topics 【 display / non-display

  • Function of endothelial cell-specific receptor, Robo4 in inflammation
    Pharmaceutical hygiene and biochemistry-related

  • New strategy for anti-inflammatory and anti-cancer therapy targeting Robo4
    Pharmaceutical hygiene and biochemistry-related

  • Endothelial cell type-specific gene expression regulated by transcription factors and epigenetic controls.
    Pharmaceutical hygiene and biochemistry-related

  • Pharmaceutical hygiene and biochemistry-related

Academic Society Membership 【 display / non-display

  • The Japanese Vascular Biology and Medicine Organization

 

Academic Papers 【 display / non-display

  • Anti-claudin antibodies as a concept for development of claudin-directed drugs., Hashimoto Y, Okada Y, Shirakura K, Tachibana K, Sawada M, Yagi K, Doi T, Kondoh M , J Pharmacol Exp Ther, 2018.12, Papers

  • The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation , Shirakura K, Ishiba R, Kashio T, Funatsu R, Tanaka T, Fukada SI, Ishimoto K, Hino N, Kondoh M, Ago Y, Fujio Y, Yano K, Doi T, Aird WC, Okada Y, J Cell Sci.,in press, 2018.12, Papers

  • Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5., 1. Hashimoto Y, Zhou W, Hamauchi K, Shirakura K, Doi T, Yagi K, Sawasaki T, Okada Y, Kondoh M, Takeda H., Sci Rep.,30;8(1):8383. , 2018.05, Papers

  • ETV2-TET1/TET2 complexes induce endothelial cell-specific Robo4 expression via promoter demethylation., Tanaka T, Izawa K, Maniwa Y, Okamura M, Okada A, Yamaguchi T, Shirakura K, Maekawa N, Matsui H, Ishimoto K, Hino N, Nakagawa O, Aird WC, Mizuguchi H, Kawabata K, Doi T, Okada Y., Scientific Reports,8: 5653, 2018.04, Papers

  • Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2., Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Kondoh M., Eur J Pharm Sci.,117:161-167, 2018.02, Papers

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Awards 【 display / non-display

  • The Pharmaceutical Society of Japan Award for Young Scientists, Yoshiaki Okada, The Pharmaceutical Society of Japan, 2013.03