School personnel information

写真b

NAGAI Yoshitaka


Keyword

Neurology, Neuroscience, Molecular Biology, Biochemistry, Medical Genetics

Mail Address

Mail Address

Laboratory Phone number

+81-6-6879-3564

Laboratory Fax number

+81-6-6879-3569

Gender

Male

Organization 【 display / non-display

  • 2001.03.01 - 2005.03.31, Graduate School of Medicine, Research Assistant

  • 2005.04.01 - 2007.03.31, Division of Preventive and Environmental Medicine, Graduate School of Medicine, Research Assistant

  • 2007.04.01 - 2007.04.30, Division of Preventive and Environmental Medicine, Graduate School of Medicine, Assistant Professor

  • 2007.05.01 - 2008.09.30, Division of Preventive and Environmental Medicine, Graduate School of Medicine, Associate Professor

  • 2016.01.01 - , Graduate School of Medicine, Professor

Education 【 display / non-display

Osaka University Faculty of Medicine  Graduated 1990.03
Osaka University Graduate School, Division of Medicine  Completed 1995.03

Employment Record 【 display / non-display

Duke University Medical Center, Research Associate 1997.07 - 2000.03
Japan Society for the Promotion of Science, Research Fellow 2000.04 - 2001.02
Osaka University, Assistant Professor 2001.03 - 2007.04
Osaka University, Associate Professor 2007.05 - 2008.09
Osaka University, Professor 2016.01 -

Research topics 【 display / non-display

  • Study on molecular pathogenesis and therapy for neurodegenerative diseases
    Neurology-related, Function of nervous system-related

  • Study on molecular pathogenesis of conformational diseases caused by misfolded proteins
    Neurology-related, Function of nervous system-related, Pathological biochemistry-related

  • Study on molecular mechanisms of amyloid fibril formation and its inhibition
    Molecular biology-related, Neurology-related

  • Study on molecular mechanisms of protein quality control systems
    Cell biology-related, Molecular biology-related

  • Study on molecular pathogenesis and therapy for microsatellite repeat expansion diseases
    Neurology-related, Function of nervous system-related, Molecular biology-related

Academic Society Membership 【 display / non-display

  • The Japan Neuroscience Society

  • Japan Society of Human Genetics

 

Academic Papers 【 display / non-display

  • A toxic monomeric conformer of the polyglutamine protein., Nagai Y., Inui T., Popiel H.A., Fujikake N., Hasegawa K., Urade Y., Goto Y., Naiki H., Toda T., Nature Structural & Molecular Biology,14(4) 332-340, 2007.04, Papers

  • Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the multicellular organismal level., Takeuchi T., Suzuki M., Fujikake N., Popiel H.A., Kikuchi H., Futaki S., Wada K., Nagai Y., Proceedings of the National Academy of Sciences of the United States of America,112(19) E2497-2506, 2015.05, Papers

  • Glucocerebrosidase deficiency accelerates an accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease., Suzuki M., Fujikake N., Takeuchi T., Kohyama-Koganeya A., Nakajima K., Hirabayashi Y., Wada K., Nagai Y., Human Molecular Genetics,24(23) 6675-6686, 2015.12, Papers

  • Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila., Nagai Y., Fujikake N., Ohno K., Higashiyama H., Popiel H. A., Rahadian J., Yamaguchi M., Strittmatter W. J., Burke J. R. and Toda T., Human Molecular Genetics,12(11) 1253-1260, 2003.06, Papers

  • The IncRNA hsrw regulates arginine dimethylation of FUS to cause its proteasomal degradation in Drosophila., Lo Piccolo L, Mochjizuki H, Nagai Y., Journal of Cell Science,132(20), 2019.11, Papers

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Patents / Utility models / Designs 【 display / non-display

  • United States, Compounds that selectively bind to expanded polyglutamine domains and methods of use thereof., James R. Burke, Warren J. Strittmatter, Yoshitaka Nagai., 6632616(Registration), 2001.02, 2003.10

Awards 【 display / non-display

  • The Award for Young Investigator of Japanese Society for Neurochemistry, Yoshitaka Nagai, Japanese Society for Neurochemistry, 2003.09