School personnel information


Kai Toshie


germline cells, germline stem cells, non coding RNA


Organization 【 display / non-display

  • 2015.10.01 - , Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Professor

Research topics 【 display / non-display

  • Thought higher animals do die as individuals, their species are maintained by sexual reproduction. Individuals are just like vehicles in which passenger -genetic information- can ride to be inherited to next generation by germline lineage. As such, germline cells are the most important cells to maintain the species. Drosophila melanogaster is one of the ideal model organisms we can study gametogenesis. How are germline stem cells maintained in the microenvironment, niche? What is the molecular mechanism that controls germline cells to mature into egg and sperm? How genome in germline cells safely guarded by non-coding RNA from transposons attacks? Our group has been addressing such molecular mechanisms for better understanding of gametogenesis.
    Developmental biology-related


Academic Papers 【 display / non-display

  • Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila, Teo RYW, Anand A, Sridhar V, Okamura K, Kai T, Nature Communications,9:1735, 2018.05, Papers

  • Protecting and diversifying the germline., Gleason RJ, Anand A, *Kai T, *Chen X, GENETICS,208(2):435-471 (A part of FLY BOOK), 2017.02,, Papers

  • The piRNA pathway is developmentally regulated during spermatogenesis in Drosophila., Quénerch’du E, Anand A and Kai T., RNA,22(7) 1044-1054, 2016.07, Papers

  • A piece of the pi(e): the diverse roles of animal piRNAs and their PIWI partners., Lim RSM and Kai T., Sem. Cell Dev. Biol. (Special Issue on Coding and Non-coding RNAs),47-48 17-31, 2015.12, Review Papers

  • The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster. , Patil VS, Anand A, Chakrabarti, A and Kai T., BMC Biol.,12 61-75, 2014.10, Papers

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