School personnel information


YEN Hilo


Microbiology, bacterial infection

Organization 【 display / non-display

  • 2011.04.01 - 2014.03.31, Division of Medicine, Graduate School of Medicine, Assistant Professor

  • 2014.04.01 - 2014.09.30, Immunology Frontier Research Center, Specially Appointed Researcher

  • 2014.10.01 - , Division of Health Sciences, Graduate School of Medicine, Assistant Professor

Employment Record 【 display / non-display

Osaka University. Assistant Professor 2011.04 - 2014.03
Osaka University, iFReC, Specially Appointed Researcher 2014.04 - 2014.09
Osaka University, Grad sch Med, Div Health Sci, Assistant Professor 2014.10 -

Research topics 【 display / non-display

  • The aim of my study is to understand how EHEC and EPEC (Enterohemorrhagic and pathogenic E. coli) employe various strategies to subvert host cell functions in order to establish the infection. Currently, I am focusing on the immunological regulatory mechanism used by these pathogens on the host cells.


Academic Papers 【 display / non-display

  • NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA, Yen H, Ooka T, Iguchi A, Hayashi T, Sugimoto N, Tobe T, PLoS Pathogens, 2010.12, Papers

  • Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation, Yen, Hilo Sugimoto, Nakaba Tobe, Toru, PLoS Pathogens,11,6,e1005121, 2015.09, Papers

  • Enterohaemorrhagic Escherichia coli produces outer membrane vesicles as an active defense system against antimicrobial peptide LL-37, Akiko Urashima, Ayano Sanou, Hilo Yen, Toru Tobe, Cellular Microbiology,10.1111/cmi.12758, 2017.06, Papers

  • Activation of lpxR gene through enterohaemorrhagic Escherichia coli virulence regulators mediates lipid A modification to attenuate innate immune response, Ogawa R, Yen H, Kawasaki K, Tobe T, Cellular Microbiology, 2018.01, Papers

  • Modulation of the Inflammasome Signaling Pathway by Enteropathogenic and Enterohemorrhagic Escherichia coli, Yen, Hilo Karino, Masaki Tobe, Toru, Frontiers in Cellular and Infection Microbiology,6,89, 2016.08, Review Papers

display all >>