School personnel information

写真b

Iguchi Tokuichi


Keyword

Neuroscience, Molecular Neuroscience, Developmental Neuroscience, Neuroanatomy

URL

http://www.anat2.med.osaka-u.ac.jp/

Organization 【 display / non-display

  • 2013.10.01 - , Division of Medicine, Graduate School of Medicine, Assistant Professor

Research topics 【 display / non-display

  • Molecular mechanism of the cortical development: formation of neural circiuts with subcortical structures.

    The neocortex controls many subcortical regions. Especially, what we call `pyramidal tract' is one major subcortical projection, which is essential for exerting motor function. During the development of pyramidal tract, axon collaterals protrude form their main shaft toward the nuclei such as superior colliculi, pontine nuclei, and inferior olivary nuclei. However, the molecular mechanisms by which axon collaterals are induced and projected to the specific regiond of the brain are mostly unknown.

    We are currently studying how the pyramidal tract is formed, especially focusing on how collaterals from the main pyramidal tract targets onto the pons, which is the most important relay structure between the cerebral cortex and the cerebellum. We developed the gene expression/ knockdown techniques in the pyramidal tract and/or pontine nuclei by the in utero electroporation method, primary culture of cortical neurons and organ culture of the brain tissues in the collagen gels. Using these techniques we now trying to to identify the molecules, which are involved in the regulation of collateral formation, and to disclose the signaling mechanisms that reorganize the cytoskeleton during the axon collateralization.

    Although we focus on this projection, underlying molecular mechanisms are so common that we can apply our knowledge to find the way to rebuild the repair brain as well as to understand/cure other neurological diseases due to malformation/malfunction of neural circuits.

    Neuroscience-general-related

Academic Society Membership 【 display / non-display

  • Society for Neuroscience

 

Academic Papers 【 display / non-display

  • Autism-associated protein kinase D2 regulates embryonic cortical neuron development., Matsumura K, Baba M, Nagayasu K, Yamamoto K, Kondo M, Kitagawa K, Takemoto T, Seiriki K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Kuriu T, Iguchi T, Sato M, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T, Biochemical and biophysical research communications,519(3) 626-632, 2019.11, Papers

  • PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover, Xie MJ, Ishikawa Y, Yagi H, Iguchi T, Oka Y, Kuroda K, Iwata K, Kiyonari H, Matsuda S, Matsuzaki H, Yuzaki M, Fukazawa Y, Sato M, Scientific Reports,9(1) 4305, 2019.03, Papers

  • Functional analysis of receptor involvment in controlling axonal collateralization during brain development, Nguyen Quynh Mai, Tokuichi Iguchi, Manabu Taniguchi, Misato Yasumura, Makoto Sato,第11回神経発生討論会,1, 2018.03, Conference Report / Oral Presentation

  • 大脳皮質ニューロン軸索側枝による領野間回路形成過程の解析, 岡 雄一郎, 林 由佳, Tiong Sheena, 土井 美幸, 佐々木 達也, 猪口 徳一, 佐藤 真,第95回日本生理学会大会,1, 2018.03, Conference Report / Oral Presentation

  • Developmental Downregulation of LIS1 Expression Limits Axonal Extension and Allows Axon Pruning, Kumamoto, T. Iguchi, Sato,M. Hirotsune, S, Biol. Open, 2017.07, Papers

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Books 【 display / non-display

  • Dictionary, Brain Science Dictionary, Tokuichi Iguchi, Makoto Sato, Editorial Committee of Brain Science Dictionary, 2013.09